If you have started researching treatments for tired, dull or crepey skin, you have probably met three names that get used almost interchangeably: Profhilo, polynucleotides and skin boosters. They are related — all are injected to improve skin quality rather than to add volume or change your shape — but they work in different ways and suit different concerns. Here is how to tell them apart.
Skin boosters: deep hydration
Skin boosters are injectable hydrators. They deliver hyaluronic acid (a substance your skin produces naturally) into the skin to draw in and hold water, improving suppleness, smoothness and that healthy, dewy look. Think of them as hydration from within rather than from a cream. They suit skin that looks dehydrated, flat or lacking glow, and are often used in a short initial course followed by maintenance.
Profhilo: bio-remodelling
Profhilo also uses hyaluronic acid, but at a very high concentration and placed at specific points so it spreads across an area. Beyond hydrating, it works as a "bio-remodelling" treatment — supporting firmness and that subtle bounce-back quality skin tends to lose over time. People often choose it when skin has started to look a little lax or tired across the cheeks, neck or hands, and they want an overall lift in skin quality rather than treatment of one line.
Polynucleotides: regeneration
Polynucleotides are a regenerative treatment. Rather than mainly hydrating, they are designed to support the skin's own repair and renewal processes, which is why they are popular for areas that need genuine conditioning — including the delicate under-eye area, where they are sometimes used to improve the look of crepey, tired skin. Because the under-eye is sensitive and results depend heavily on suitability, this is one we always assess in a consultation first.
So which one do you need?
Honestly — that is the wrong question to start with. The right starting point is the concern: Is your skin dehydrated and dull? Starting to lose firmness? Crepey under the eyes? The answer points toward the most appropriate treatment, and sometimes the answer is a combination over time, or a good skincare routine first. None of these is a magic fix, and more is not better.
How a consultation decides
At your consultation, Nurse Khloe assesses your skin, talks through what is realistic and recommends a plan made only for you — including being honest if a treatment would not serve you, or if none is needed yet. Some of these treatments can be booked directly once you understand them; others, like polynucleotides, are assessed first for suitability. Either way, you will leave understanding your options, with no pressure to proceed.
This article is general information, not medical advice, and does not replace a personal consultation. Suitability for any treatment is assessed individually. Results vary from person to person.